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dna capture and sequencing of exomes  (Baylor Genetics)

 
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    Baylor Genetics dna capture and sequencing of exomes
    Dna Capture And Sequencing Of Exomes, supplied by Baylor Genetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dna+capture+and+sequencing+of+exomes/dna+capture+and+sequencing+of+exomes/pmc07928427__mmc2-16-11-25
    Average 90 stars, based on 1 article reviews
    dna capture and sequencing of exomes - by Bioz Stars, 2026-10
    90/100 stars

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    Sequencing:

    Article Title: Germline mutation in POLR2A : a heterogeneous, multi-systemic developmental disorder characterized by transcriptional dysregulation
    Article Snippet: .. For individuals 1, 6, and 8–13, DNA capture and sequencing of exomes was carried out as previously described by Hansen et al. at either the Baylor Genetics (BG) laboratories or at the Baylor College of Medicine Human Genome Sequencing Center (HGSC). .. Sequencing and analysis for individuals 2 (genome sequencing) and 5 (exome sequencing [ES]) were provided by the Broad Institute of MIT and Harvard Center for Mendelian Genomics (Broad CMG).

    Article Title: Germline mutation in POLR2A : a heterogeneous, multi-systemic developmental disorder characterized by transcriptional dysregulation
    Article Snippet: .. For individuals 1, 6, and 8–13, DNA capture and sequencing of exomes was carried out as previously described by Hansen et al.7 at either the Baylor Genetics (BG) laboratories or at the Baylor X, USA; 2Department of Molecular and Human Genetics, Baylor College of ty of Pittsburgh, Pittsburgh, PA, USA; 4Department of Biochemistry and er Hospital for Children, Orlando Health, Orlando, FL, USA; 6Broad Center road Institute of MIT and Harvard, Cambridge, MA, USA; 7Departments of , USA; 8Texas Scottish Rite Hospital for Children, Dallas, TX, USA; 9DepartX, USA; 10Baylor Genetics Laboratories, Houston, TX, USA; 11Victorian ClinVIC, Australia; 12Department of Paediatrics, University of Melbourne, Parkroscience, Department of Pediatrics, Baylor College of Medicine, Houston, ine, Houston, TX, USA; 15Jan and Dan Duncan Neurological Research Insti- , Houston, TX, USA; 17Department of Pediatrics, Baylor College of Medicine, .) ..



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    A nonsense mutation of PTPN4 is identified in 1 case of rectal cancer. A, Computer tomography image of abdomen and pelvic cavity. Tumor (red triangle) thickened rectal wall (right side) and dilated the abdominal intestines (left side). B, PTPN4 had a mutation with the highest mutation ratio. A total of 98 somatic mutated genes were identified in 1 case of rectal cancer by exome capture <t>DNA</t> <t>sequencing.</t> C, A c.549dupT mutation enabled PTPN4 to obtain a premature stop codon. D, The molecular weight of wild PTPN4 encoded by 3Flag‐PTPN4 is >100 kDa, while protein encoded by 3Flag‐PTPN4 c.549dupT is <30 kDa. E, The expression of PTPN4 was negative in the rectal tumor tissue, whereas the positive PTPN4 was observed in the paired adjacent normal tissue. F, Several somatic mutations of PTPN4 were found in rectal cancer samples from the TCGA READ database. Somatic mutations in PTPN4 occur mainly in patients with heavy tumor burden
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    Image Search Results


    A nonsense mutation of PTPN4 is identified in 1 case of rectal cancer. A, Computer tomography image of abdomen and pelvic cavity. Tumor (red triangle) thickened rectal wall (right side) and dilated the abdominal intestines (left side). B, PTPN4 had a mutation with the highest mutation ratio. A total of 98 somatic mutated genes were identified in 1 case of rectal cancer by exome capture DNA sequencing. C, A c.549dupT mutation enabled PTPN4 to obtain a premature stop codon. D, The molecular weight of wild PTPN4 encoded by 3Flag‐PTPN4 is >100 kDa, while protein encoded by 3Flag‐PTPN4 c.549dupT is <30 kDa. E, The expression of PTPN4 was negative in the rectal tumor tissue, whereas the positive PTPN4 was observed in the paired adjacent normal tissue. F, Several somatic mutations of PTPN4 were found in rectal cancer samples from the TCGA READ database. Somatic mutations in PTPN4 occur mainly in patients with heavy tumor burden

    Journal: Cancer Science

    Article Title: Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer

    doi: 10.1111/cas.14031

    Figure Lengend Snippet: A nonsense mutation of PTPN4 is identified in 1 case of rectal cancer. A, Computer tomography image of abdomen and pelvic cavity. Tumor (red triangle) thickened rectal wall (right side) and dilated the abdominal intestines (left side). B, PTPN4 had a mutation with the highest mutation ratio. A total of 98 somatic mutated genes were identified in 1 case of rectal cancer by exome capture DNA sequencing. C, A c.549dupT mutation enabled PTPN4 to obtain a premature stop codon. D, The molecular weight of wild PTPN4 encoded by 3Flag‐PTPN4 is >100 kDa, while protein encoded by 3Flag‐PTPN4 c.549dupT is <30 kDa. E, The expression of PTPN4 was negative in the rectal tumor tissue, whereas the positive PTPN4 was observed in the paired adjacent normal tissue. F, Several somatic mutations of PTPN4 were found in rectal cancer samples from the TCGA READ database. Somatic mutations in PTPN4 occur mainly in patients with heavy tumor burden

    Article Snippet: Whole‐exome capture DNA sequencing service was provided by GenomiCare Biotechnology (Shanghai).

    Techniques: Mutagenesis, Tomography, DNA Sequencing, Molecular Weight, Expressing